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Clinical evidence
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Evidence that builds confidence
Explore references on optical newborn assessment, with access to original sources and a clear description of each publication type.
Featured publications and resources
Protocol · preprint
2026 · Research Square
APPLE: evaluation across birth settings
Multicenter cohort protocol on postnatal assessment with PreemieTest. A preprint without journal peer review; it does not report final results.
Technical documentation
2024 · BirthTech · version 05
PreemieTest instructions for use
The official manual made available by BirthTech. A technical use resource, distinguished from clinical studies.
Lung maturity
25/12/2023 · JMIR Biomedical Engineering
Skin maturity and its association with lung maturity
A secondary-outcomes analysis of a clinical trial examining LED-based skin maturity assessment and its association with lung maturity.
Respiratory risk
15/11/2023 · Frontiers in Pediatrics
Predicting respiratory distress syndrome at birth
Development and validation of machine learning models using optical skin maturity assessment to estimate respiratory risk in limited-resource settings.
Classification at birth
28/03/2023 · Frontiers in Pediatrics
Gestational age by optical skin reflection in low-birth-weight newborns
A study of how gestational age estimated through optical skin reflection can support classification of low-birth-weight newborns at birth.
Systematic review
11/02/2023 · BMC Pregnancy and Childbirth
Gestational age dating methods and classification at birth
A systematic review and meta-analysis examining how gestational age dating methods influence reported proportions of preterm and small-for-gestational-age births.
Clinical validation
07/09/2022 · Journal of Medical Internet Research
Device validation for gestational age prediction
Clinical validation of a newborn skin maturity assessment device. Read the article for its methods, results and limitations.
Multicentre protocol
14/07/2020 · JMIR Research Protocols
Preterm or small for gestational age?
An international multicentre trial protocol evaluating classification of low-birth-weight newborns through the optical properties of the skin. Study protocol; no final results reported.
Methodological resource
04/10/2019 · protocols.io
Assessment of newborn skin maturity
Research protocol standardising Preemie-Test assessment in clinical studies.
Clinical protocol
05/03/2019 · BMJ Open
Preemie-Test multicentre trial protocol
Study design for evaluating a device based on the interaction between light and newborn skin in Brazilian hospitals.
Proof of concept
20/09/2017 · PLOS ONE
Skin reflection and gestational age prediction
A cross-sectional study exploring newborn skin optical properties as an approach to gestational age prediction.
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